Abstract

OSIO, Luis Fernando et al. Antiphospholipid syndrome: description of a cohort of 32 patients in southwestern Colombia. Rev.Colomb.Reumatol. [online]. 2010, vol.17, n.3, pp.172-177. ISSN 0121-8123.

Introduction. The antiphospholipid syndrome (SAF), is an autoinmune disorder characterized by a combination of thrombosis phenomena, recurrent fetal losses and elevated titles of antiphospholipid antibodies. The form of presentation in our country is little unwell known. Objective. To describe the clinical and immunological manifestations of one cohort of patients with SAF in the colombian southwest. Methods. We describe a cohort of patients with diagnosis of SAF in the Fundación Valle del Lili, Cali, Colombia, evaluated between august 2001 and june 2007. A data base to registry and analysis of the clinical and immunological manifestations was performed. Results. 32 patients were evaluated. Average of age was 39,03 ± 12,6 years. The average time of evolution of disease was 8 years. 28 patients were women (87,5%). Primary SAF appeared in 20 patients (62,5%). The most frequent manifestations were the venous thrombosis (59,4%), arterial thrombosis (31,3%) and the obstetrical complications (30% of the women). Antibodies anticardiolipins IgG were positive in 20 patients (62,5%), IgM in 18 (56,3%). 9 patients (28.1%) were VDRL falsely positive. Lupus anticoagulant (LAC) was presented in 8 (25%). The most significant correlations were: deep venous thrombosis (TVP) with pulmonary tromboembolism (p 0,01), positivity for anticardiolipin of the IgG type with cutaneous manifestations and TVP (p 0,05 respectively), positivity for anticardiolipina IgM with thrombosis in the site of vascular accesses (p 0,05) and neurological manifestations with LAC presence (p 0,05). Conclusions. The clinical and immunological characteristics of the patients with SAF in the colombian southwest do not defer from other similar series in Colombia or other countries. Some correlations between particular autoantibodies and clinical aspects are report.

Keywords : antiphospholipid syndrome; antiphospholipids antibodies; Colombia.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )