Abstract

BAUTISTA MOLANO, Wilson et al. Role of periodontal disease in the development of autoimmune inflammatory entities clinical: implications and therapeutic challenges. Rev.Colomb.Reumatol. [online]. 2012, vol.19, n.2, pp.84-91. ISSN 0121-8123.

During the last decade the knowledge related to the pathogenesis of odontogenic infections and their possible association with systemic diseases has been of great interest. Periodontal pathogens that enter to bloodstream are involved in systemic pathological effects. The Focal Infection Theory is based on the pathophysiology correlation between chronic periodontitis and the development of certain autoimmune diseases. Rheumatoid arthritis as inflammatory disease is characterized by persistent synovitis and destruction of cartilage and bone. The etiology is uncertain, but some microorganisms may play important role in the lack of self- tolerance and the consequent development of autoimmunity. P. gingivalis may be involved in amplifying the immune response and induction of the disease in individuals with genetic susceptibility. Therefore, the concept of periodontal medicine as a discipline to integrate these associations has emerged.

Keywords : focal infection; dental; periodontitis; inflammation; arthritis rheumatoid.

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