Abstract

MARTIN MARIN, Myriam Lorena et al. Non-lupus "full house" nephropathy, clinical and histological aspects. Experience in two hospitals in Medellín, Colombia. Rev.Colomb.Reumatol. [online]. 2012, vol.19, n.3, pp.124-130. ISSN 0121-8123.

Introduction: Most patients with "full house" nephropathy (defined as the simultaneous detection of deposits of IgA, IgM, IgG, C1q and C3) have systemic lupus erythematosus (SLE), however, there is a group of diseases that can manifest with "full house" nephropathy without lupus: liver disease, diabetes mellitus, primary glomerular diseases, C1q nephropathy, IgA nephropathy and infections. Objective: To describe clinical characteristic, histological findings and evolution of non-lupus "full-house" nephropathy in patients from two institutions of Medellín, Colombia. Methods: 20 patients were included with non-lupus "full-house" nephropathy, evaluated between 2004 y 2010 in two medical centers in Medellín, Colombia: Hospital Universitario San Vicente Fundación and Hospital Pablo Tobón Uribe, who had 6 months o more follow up. We analyzed Myriam L. Martín, et al. Nefropatía "full house" no lúpica, aspectos clínicos e histológicos clinical, laboratory and histology findings. The results are displayed as summary measures and dispersion, according to the type of variable. Results: 20 records of patients were included (12 children and 8 adults). The ages ranged from 10-54 years (mean: 23.2 ± 14.5 years), female predominance (80%). The more frequent histological diagnoses was: membranous glomerulonephritis (50%), The average follow-up time was 40.9 months ± 24.8. Two patients developed antinuclear antibodies (ANA) without fulfilling the classification criteria for SLE. Conclusions: "Full house" nephropathy is a diagnostic challenge, may be associated with other systemic diseases, with primary renal disease or infection, has a variable clinical expression and histologic findings are diverse. At follow-up should always be alert to the possible development of SLE.

Keywords : "Full house" nephropathy; non-lupus "full house" nephropathy; systemic lupus erythematosus.

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