Abstract

ZULUAGA GOMEZ, Liliana María; VELASQUEZ FRANCO, Carlos Jaime; HERNANDEZ FORONDA, John Camilo  and  CASTANO ALZATE, Carlos Felipe. Rituximab use in a patient with diffuse necrotizing anterior scleritis associated to c-ancas vasculitis refractory to conventional inmunomodulators. Rev.Colomb.Reumatol. [online]. 2012, vol.19, n.3, pp.183-189. ISSN 0121-8123.

Scleritis is a rare disease characterized by inflammation of sclera and underlying infectious or systemic disease. Severe cases can compromise vision and cause scleral necrosis and eye perforation. c-ANCA associated vasculitis, a systemic syndrome could cause scleritis. Traditional treatment consists of antinflammatory and immunomodulators administration. Refractory cases could be treated with monoclonal antibodies. We report the case of a woman with diffuse necrotizing anterior scleritis associated to c-ANCA refractory to immunosupressants, such as cyclophosphamide in which only Rituximab could induce remission.

Keywords : Scleritis; anti-neutrophil cytoplasmic antibody-associated vasculitis; rituximab; therapy.

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