Abstract

POLANCO FLORES, Nasser Abdel; SOTO ABRAHAM, María Virgilia  and  RODRIGUEZ CASTELLANOS, Francisco Eugenio. Clinicopathological presentation of lupus nephritis: Experience in a Mexican center. Rev.Colomb.Reumatol. [online]. 2013, vol.20, n.2, pp.80-90. ISSN 0121-8123.

Background: Lupus nephritis is the leading cause of chronic kidney disease, and requires renal replacement treatment. There is not much information about its clinicopathological presentation and evolution in the Mexican population. Objective: To describe the clinical, histological and treatment characteristics of lupus nephritis patients attended in our institution. Methods: This is an observational, longitudinal, and retrospective study. Lupus nephritis patients underwent at least one renal biopsy between January 2004 and January 2012. Results: A total of 100 patients were included, of whom 85% were female. The mean onset of lupus nephritis was 13.1±28.1 months, with 63% of patients with a creatinine below 1.3 mg/dL. The most common clinical presentation was nephritic and hematuria-proteinuria syndrome in 68% of cases. Proliferative nephropathy was found in 79% of patients. All patients received the treatment indicated by their nephrologist. A second biopsy was performed on 57% of the patients 12 months after the therapeutic intervention. The findings in the second biopsy led to a modification in immunosuppressive agents in 81% of patients (46/57). Only 10% of the population required dialysis at 12 months. Conclusions: Early detection and referral of patients with lupus nephritis allows a treatment that could limit the rapid deterioration of renal function and chronic kidney disease progression.

Keywords : Lupus erythematosus systemic; Lupus nephritis; Biopsy; Kidney.

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