Abstract

CUBIDES, Héctor Hernán; MORA K, Claudia Marcela; PARRA I, Leydi Viviana  and  LONDONO P, John. Profile of Th17 cytokine and its role in the pathophysiology and potential use as biomarkers in the activity of systemic lupus erythematosus. Rev.Colomb.Reumatol. [online]. 2015, vol.22, n.4, pp.217-224. ISSN 0121-8123.  https://doi.org/10.1016/j.rcreu.2015.08.002.

Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease expressed in genetically predisposed individuals. The interaction of a trigger factor together with the failure of the mechanisms for handling potential reactive autoantigens leads to the development of immune complex responsible for the damage of the target organs. Elements of both innate and adaptive immunity have been implicated in the pathophysiology of the disease, but given the heterogeneity of the SLE, we still do not have a biological marker of activity of the disease with high sensitivity, specificity and predictive value. Recently, a cell population was described as lymphocytes T helper 17 (Th17), so called because of their production of Interleukin 17 (IL-17), cytokine that mediates physiological and pathophysiological processes implicated in the development of inflammatory conditions such as SLE. It has been postulated that serum IL-17 may be a biomarker that meets these parameters; however, data on this topic is still incomplete. We present a review of the ontogenetic mechanisms of Th17 lymphocytes, an explanation of its pathophysiological role in SLE and clinical studies that support and discuss the role of Th17 lymphocytes related cytokines as biomarkers of disease activity in SLE.

Keywords : Systemic lupus erythematosus; Th17 cells; Interleukin 17 (IL-17); Biomarker.

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