Resumo

OSPINA, Fabio Enrique et al. Role of the cytokine BAFF in autoimmune diseases: physiopathology and therapeutic targets. Rev.Colomb.Reumatol. [online]. 2016, vol.23, n.3, pp.177-194. ISSN 0121-8123.  https://doi.org/10.1016/j.rcreu.2016.06.003.

The BAFF complex (B cell activator factor) composed by the BAFF cytokine, APRIL and their receptors -BAFF-R (BR3), TACI, BCMA- influences B-lymphocyte maturation, peripheral survival and immunoglobulins class isotype switching, with multiple potential clinical implications. In this review we discuss BAFF biologic functions and it relevance in several clinical disorders -autoimmune, neoplastic, infectious and BAFF therapies-. BAFF/APRIL.

Palavras-chave : BAFF; APRIL; BCMA; TACI; Belimumab; Autoimmune diseases.

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