Resumo

ENCALADA-GARCIA, Carlos. Dendritic cells and interferons in systemic lupus erythematosus. Rev.Colomb.Reumatol. [online]. 2017, vol.24, n.3, pp.177-184. ISSN 0121-8123.  https://doi.org/10.1016/j.rcreu.2017.04.002.

Systemic Lupus Erythematosus (SLE) is an autoimmune disorder with a genetic basis, and is characterised by the appearance of autoantibodies, the formation and deposition of circulating immune complexes, and chronic inflammation in various organs.

It is of multifactorial origin, and in genetically predisposed individuals, environmental factors and hormonal components play a key role in the immune system of the disease. About 25 genetic loci have been identified, indicating the importance in this pathology. However, the concordance rate for SLE is only 25% among monozygotic twins.

An example of this is the deficiencies of the initial components in the classical serum complement pathway such as C1q, C2 or C4, which, although rare, confer genetic susceptibility for SLE at a rate of 30% in the case of C4 deficiency, and more than 90% for C1q deficiency.

It was also demonstrated that C1q inhibits plasmacytoid dendritic cells (pDCs) in the secretion of interferon-alpha (IFN-a), thus providing a new link between complement deficiency and activation of the IFN pathway.

Therefore, IFN-a is considered to have a central role in the pathogenesis of SLE, with high serum concentrations being found in outbreaks of this disease.

These IFN exert prominent immunoregulatory effects, suggesting that this cytokine is key, not only in the innate immune system, but also in adaptive immune responses.

Taking these facts into account, it can be anticipated that pDCs, the main source of IFN secretion, are involved in this autoimmune disease.

In this review, we will focus on the participation of pDCs and IFNs in SLE.

Palavras-chave : Systemic lupus erythematosus (SLE); Dendritic cells; Interferon.

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