Abstract

MENDEZ-RAYO, Tatiana et al. Interpretation of autoantibodies in rheumatological diseases. Rev.Colomb.Reumatol. [online]. 2018, vol.25, n.2, pp.112-125. ISSN 0121-8123.  https://doi.org/10.1016/j.rcreu.2018.02.004.

Autoimmune diseases are a group of chronic diseases in which genetic, environmental, and hormonal factors contribute to their appearance. In addition to having a broad clinical spectrum, the interpretation of the various autoantibodies and techniques used in the laboratory is also a clinical challenge. Given the complexity of these diseases, it is very important to rely on the results of laboratory tests to establish a correct diagnosis and follow-up and, in some cases even to establish a prognosis or prediction of autoimmunity. Taking all this into account, it is intended to improve the quality of life of patients by decreasing the increased morbidity and mortality in this group of diseases, especially by early diagnosis. Most rheumatological diseases are characterized by the high production of autoantibodies and acute phase reactants, which are involved in their pathophysiology, leading to systemic involvement. Among these, the most recognized are, systemic lupus erythematosus, rheumatoid arthritis, and Sjögren's syndrome. For these reasons, the objective of this project is to present a review that will help both physicians and laboratory personnel in the interpretation of the different autoantibodies in autoimmune diseases.

Keywords : Autoimmunity; Autoantibodies; Systemic lupus erythematosus; Rheumatoid arthritis; Sjögren's syndrome; Indirect immunofluorescence technique; Enzyme-linked immunosorbent assay; Antinuclear antibodies; Rheumatoid factor; Anti-cyclic citrullinated peptide.

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