SciELO - Scientific Electronic Library Online

 
vol.25 issue3Determination of vitamin D (25[OH]D) levels in renal transplant patients and their importance in accordance with the glomerular filtration ratePerception of quality of life in patients with osteoarthritis. Sociodemographic and clinical characteristics. A 5 year study author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google

Share


Revista Colombiana de Reumatología

Print version ISSN 0121-8123

Abstract

FACIO-LINCE GARCIA, Andrea et al. Characteristics of nailfold videocapillaroscopy and antinuclear antibodies in a cohort of patients with systemic autoimmune disease with Raynaud's phenomenon. Rev.Colomb.Reumatol. [online]. 2018, vol.25, n.3, pp.169-176. ISSN 0121-8123.  https://doi.org/10.1016/j.rcreu.2018.06.003.

Introduction:

Between 15 and 20% of patients with Raynaud's phenomenon will progress to a systemic autoimmune disease. The presence of autoantibodies or capillaroscopy alterations are fundamental for early diagnosis.

Objectives:

To determine the characteristics of nailfold videocapillaroscopy and antinuclear antibodies in a cohort of patients with systemic autoimmune disease.

Materials and methods:

A cross-sectional study was conducted in subjects with Raynaud s phenomenon. These were evaluated with videocapillaroscopy and antinuclear antibodies. The qualitative variables were described with absolute and relative frequencies. The quantitative variables, according to the distribution of data, were reported as mean or median, with standard deviation and interquartile range, respectively.

Results:

The study included 58 individuals, of which 91.4% were women. The mean age was 40.9 ± 14.1 years. Antinuclear antibodies were positive in 41 subjects. The most common pattern was speckled (41.5%), with a median dilution of 1:640 (interquartile range 1:3201:1,280). A systemic autoimmune disease was found in 10 (19.2%) patients, 8 of them with systemic sclerosis. The most frequent capillary alterations were: mega-capillaries (n = 10), micro-haemorrhages (n = 10), and avascular zones (n = 8).

Conclusions:

In this group of patients with Raynaud's phenomenon subjected to videocapillaroscopy, a diagnosis of systemic autoimmune disease was made in a similar percentage to that reported in the literature. A higher dilution of antinuclear antibodies was found than that described.

Keywords : Raynaud's disease; Microscopic angioscopy; Antinuclear antibodies; Autoimmune diseases.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )