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Revista Colombiana de Reumatología

Print version ISSN 0121-8123


HORMAZA, Andrés-Alberto et al. Sublingual microcirculatory alterations in patients with stable systemic sclerosis. Rev.Colomb.Reumatol. [online]. 2018, vol.25, n.4, pp.257-260. ISSN 0121-8123.


Systemic sclerosis (SSc) is a systemic autoimmune disease characterized by fibrosis, inflammation, and microcirculatory alterations.


To evaluate abnormalities in the sublingual microcirculation of SSc patients and to establish any differences compared to healthy controls.


The sublingual microcirculation was determined using a Sidestream dark-field (SDF) imaging device (MicroScan; MicroVision Medical, Amsterdam, the Netherlands) in patients with SSc and controls.


Twelve patients with SSc (75% with diffuse cutaneous SSc) were evaluated (mean age: 52.08 ± 2.08 years). A group of 20 volunteers was used as the control. Significantly lower total capillary density (TCD) (9.2 [8.5-9.7] vs. 10.9 [9.8-12.5]) and functional capillary density (FCD) (7.0 [6.8-7.5] vs. 8.6 [7.5-9.8]) were observed in SSc patients than in healthy controls.


SSc is related to significantly lower capillary density in the sublingual microcirculation, and the SDF imaging technique could be an alternative to nailfold video-capillaroscopy for diagnosing and following-up patients with SSc.

Keywords : Scleroderma; Systemic Scleroderma; Diffuse; Microcirculation; Capillaroscopy.

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