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Revista Colombiana de Reumatología
versão impressa ISSN 0121-8123
Resumo
LOPEZ-VILLEGAS, Víctor Jaime; HINCAPIE RUBIO, Luis Miguel e RIVERA, Lina María Saldarriaga. Life-threatening hemorrhage secondary to acquired deficiency of coagulation factors VIII and XI related to systemic lupus erythematosus: case report. Rev.Colomb.Reumatol. [online]. 2019, vol.26, n.4, pp.290-293. Epub 01-Nov-2020. ISSN 0121-8123.
In patients with autoimmune diseases, the simultaneous occurrence of lupus anticoagulant and blood coagulation factors inhibitors is infrequent and is associated with hemorrhagic events. In these cases, the initial approach requires a thorough interpretation of coagulation laboratory tests and mixing studies to reach a definitive diagnosis. We report the case of a patient with systemic lupus erythematosus and Sjögren's syndrome who presented with hemorrhagic diathesis caused by circulating inhibitors against factors VIII and XI coexisting with lupus anticoagulant. The inhibitors eradication was made with rituximab, achieving good results.
Palavras-chave : Factor VIII deficiency; Factor XI deficiency; Lupus coagulation inhibitor; Systemic lupus erythematosus; Blood coagulation factor inhibitors; Rituximab.