Abstract

PADILLA-ORTIZ, Diana et al. Lung cancer acting as a trigger of autoimmunity: a medical challenge. Rev.Colomb.Reumatol. [online]. 2020, vol.27, n.3, pp.218-223.  Epub Apr 27, 2021. ISSN 0121-8123.  https://doi.org/10.1016/j.rcreu.2019.10.004.

There is a complex, dynamic, and bidirectional connection between autoimmunity and cancer. The underlying mechanisms of carcinogenesis and physiopathological aspects of autoimmune diseases are not fully understood. However, there is a common immunological base related to expression of autoantigens by tumour cells that cause an anti-cancer immune response, thereby, triggering the development of paraneoplastic rheumatic syndromes and autoimmune rheumatic diseases in a genetically predisposed population. The case is reported of a 57 year-old man presenting with pulmonary renal syndrome, and who was diagnosed lung cancer and systemic lupus erythematosus at the same time.

Keywords : Lung cancer; Systemic lupus erythematosus; Autoimmunity; Pulmonary renal syndrome; Paraneoplastic rheumatic syndromes.

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