Abstract

TANDAIPAN, Jose Luis  and  CASTELLVI, Ivan. Systemic sclerosis and gastrointestinal involvement. Rev.Colomb.Reumatol. [online]. 2020, vol.27, suppl.1, pp.44-54.  Epub Aug 21, 2021. ISSN 0121-8123.  https://doi.org/10.1016/j.rcreue.2019.12.003.

Systemic sclerosis (SSc) is a systemic autoimmune disease in which gastrointestinal manifestations are a frequent complication. Gastrointestinal involvement is present in up to 90 % of patients. The most affected areas are the esophagus and the anorectal tract. Reflux, heartburn and dysmotility are the leading causes of gastrointestinal discomfort. Disordered anorectal function can occur early in the course of SSc and is an important factor in the development of fecal incontinence. Current recommendations to treat gastrointestinal disorders in SSc include the use of proton pump inhibitors, prokinetics and rotating antibiotics. This review discusses the proposed pathophysiological mechanisms, the clinical presentation, the different diagnostic techniques and the current management of the involvement of each section of the gastrointestinal tract in SSc.

Keywords : Systemic sclerosis; Dysmotility; Chronic intestinal; pseudo-obstruction; Dysphagia; Fecal incontinence; Gastroesophageal reflux disease; Gastroparesis; Small intestinal bacterial; overgrowth.

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