Abstract

MARTINEZ-CEBALLOS, María Alejandra et al. Unstimulated whole saliva flow collection technique in the diagnosis of patients with Sjögren's syndrome: Unifying concepts. A systematic literature review. Rev.Colomb.Reumatol. [online]. 2020, vol.27, suppl.2, pp.90-101.  Epub Sep 07, 2021. ISSN 0121-8123.  https://doi.org/10.1016/j.rcreu.2020.05.016.

Introduction: Sjögren's syndrome (SS) is an autoimmune disease that compromises the function of exocrine glands, producing xerostomia and xerophthalmia. The method used to quantify saliva gland dysfunction is by unstimulated whole saliva flow (UWSF).To describe the main UWSF techniques in patients with SS. Systematic review of the literature (following PRISMA guidelines) of results that include analytical observational studies of case-control, cohort, and cross-sectional studies that include patients with sicca symptoms and diagnosis of SS by international classification criteria, which were compared with healthy subjects or those with non-Sjögren sicca symptoms, and in which the technique and the value of the UWSF was reported as the main outcome. Qualification of the level and quality of the evidence was obtained using the Oxford and Joanna Briggs Institute guidelines. A total of 29 articles were included, with total population of 2,730 patients: 1,397 cases and 1,333 controls. The most frequently reported technique was that of Navazesh by spontaneous drainage collection for 5 min. The most frequent cut-off point found was 0.1ml/min. For the first time in the literature, and by using a systematic review of the literature, a description is presented of the main techniques used to evaluate UWSF in individuals with SS when compared with healthy people or with sicca non-SS syndrome, highlighting that it is a valid, non-invasive, reproducible, and low cost technique.

Keywords : Sjögren syndrome; Saliva; Xerostomia; Dry eye syndromes; Autoimmune diseases.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )