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Revista Colombiana de Reumatología

versión impresa ISSN 0121-8123


PUERTA, Germán et al. TAFRO syndrome mimicking systemic lupus erythematosus: Case report and literature review. Rev.Colomb.Reumatol. [online]. 2022, vol.29, n.4, pp.373-383.  Epub 16-Ago-2023. ISSN 0121-8123.

TAFRO syndrome is a very rare disease, with less than 100 cases reported in the literature. It is classified as a type of idiopathic multicentric Castleman disease, but it has clinical, paraclinical, and histopathological characteristics that differentiate between TAFRO and idiopathic forms of Castleman disease not otherwise specified. However, it is a challenging exclusion diagnosis. TAFRO syndrome is characterized by systemic inflammatory involvement, often severe, which can present with kidney failure, and become a severe disease with a high mortality rate. The clinical manifestations of TAFRO can be confused with hematology malignancies or various autoimmune diseases. Although there are some reports of TAFRO syndrome associated with autoimmune compromise, there is no published consensus for the diagnosis or treatment. The case presented is a patient who meets the criteria to be classified as SLE, and with manifestations with significant clinical involvement, but with no improvement with standard treatment. It was found that the patient's systemic involvement was due to TAFRO, and that therefore the TAFRO syndrome could simulate SLE, something previously not described in the literature.

Palabras clave : Lupus; TAFRO síndrome; Multi-centric Castleman disease; Reticulin fibrosis; Organomegaly.

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