Abstract

COLINA VARGAS, Yerlin Andrés et al. HyperCKemia-MB due to macroCK type 1: Case report. Rev.Colomb.Reumatol. [online]. 2022, vol.29, n.4, pp.429-433.  Epub Aug 22, 2023. ISSN 0121-8123.  https://doi.org/10.1016/j.rcreu.2020.11.007.

HyperCKemia is a rare condition characterized by a persistent increase in serum creatine kinase (CK) levels or some isoenzymes. Usually, there are no clinical, electromyography or histological manifestations, which involves a challenge at the time of diagnosis. The patient in question showed no characteristic signs or symptoms, apart from fatigue and post-exercise myalgia. Assessment was performed by rheumatology and endocrinology, determination of total CK and MB fraction in blood, and electromyography and protein electrophoresis were requested as part of the approach. This case report is considered as novel, interesting, and useful for clinical practice as few similar ones were found in the scientific literature. The difficult etiological diagnosis of this entity, and the algorithm used to arrive at it, are all presented. It is concluded that in those patients with hyperCKemia of unknown etiology, this diagnosis should be kept in mind, and be confirmed by performing a CK electrophoresis.

Keywords : Creatine kinase; MB Form; Macro creatine kinase; HyperCKemia.

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