Abstract

GUZMAN, Guillermo et al. Hypophysitis an uncommon manifestation of IgG4-related disease: Case report. Rev.Colomb.Reumatol. [online]. 2023, vol.30, n.1, pp.67-71.  Epub Aug 19, 2023. ISSN 0121-8123.  https://doi.org/10.1016/j.rcreu.2021.04.010.

IgG4-related disease is a recently described disease that can involve various organs and systems. Single organ involvement is the exception to the rule, it is generally a multi-system entity. We present a 36-year-old woman, with no previous pathological history or autoimmune disease, with headache caused by cystic macroadenoma. A transsphenoidal resection was performed and pathology documented areas of fibrosis with a predominantly plasmolymphocytic infíltrate and positive IgG4 staining in more than 20 cells per high-power field, meeting diagnostic criteria for IgG4-related sclerosing disease. Involvement of other organs was ruled out, and the patient improved clinically after management.

Keywords : IgG4; Immunoglobulin G4-related disease; Hypophysitis.

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