Abstract

DELGADO R, Livan; FRAGA P, Ángela; BECQUER V, María  and  VAZQUEZ L, Ana. Lipofundin 20% induces hepatic lipid peroxidation in New Zealand white rabbits. Rev.MVZ Cordoba [online]. 2012, vol.17, n.3, pp.3113-3117. ISSN 0122-0268.

Objective. The aim of the present work was to evaluate the effects of Lipofundin 20% on lipid peroxidation markers in the liver of New Zealand white rabbits. Materials and methods. The animals were treated with an intravenous injection (2 ml/kg) of the lipid emulsion during 8 days through the marginal ear vein. At the end of the experiment some lipid peroxidation parameters and lipid profile were tested through spectrophotography. Results. Lipofundin was found to induce a significant (p<0.05) increase of malondialdehyde, total hydroperoxides, and peroxidation potential. Also, high levels of total cholesterol, triglycerides, LDL - cholesterol and HDL-cholesterol were observed in treated animals compared with the control group (p<0.05). Conclusions. Data proved that Lipofundin induces hepatic lipid peroxidation in rabbits, mainly through a mechanism which involves an induction of hyperlipidemia.

Keywords : Hyperlipidemia; Lipofundin; lipid peroxidation; oxidative stress; rabbits.

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