SciELO - Scientific Electronic Library Online

 
vol.23 número3In vitro production of gas methane by tropical grassesHey1 gene expression patterns during the development of branchial arches and facial prominences índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Journal

Artigo

Indicadores

Links relacionados

  • Em processo de indexaçãoCitado por Google
  • Não possue artigos similaresSimilares em SciELO
  • Em processo de indexaçãoSimilares em Google

Compartilhar


Revista MVZ Córdoba

versão impressa ISSN 0122-0268versão On-line ISSN 1909-0544

Resumo

FARIA, Joice LM et al. Acetylcholinesterase activity and total antioxidant levels in dogs with mammary tumors before and after surgical removal. Rev.MVZ Cordoba [online]. 2018, vol.23, n.3, pp.6799-6812. ISSN 0122-0268.  https://doi.org/10.21897/rmvz.1369.

Objective.

The aim of this study was to evaluate AChE activity in total blood and the FRAP levels in samples from dogs with mammary tumors before and after surgery, as well as the relationship between these variables with immunohistochemical markers of tumor (E-caderina, ki-67, COX-2).

Materials and methods.

In this study, 13 dogs with mammary tumors were divided into two groups (A and B). The group A was formed by dogs with tumors smaller than 3 cm of diameter, and the group B was formed by dogs with tumor of 3 cm of diameter or larger. The AChE activity and FRAP levels were evaluated before and after surgery and the immunohistochemistry were performed at the tumors.

Results.

The AChE activity was significantly increased (p<0.05) in dogs with mammary cancer compared to control animals, and neither surgery or tumor size affected the AChE activity (p>0.05). FRAP levels before surgery were significantly lower (p<0.05) compared to control animals. Also, FRAP levels increased significantly after surgery in animals of the group A compared to data before surgery, a fact not observed in dogs from the group B. E-cadherin showed low significant positive correlation with FRAP levels (r=0.37, p-value=0.05); COX-2 showed a moderate significant positive correlation to FRAP (r=0.55, p-value<0.05); and COX-2 showed a low significant positive correlation to AChE (r=0.32, p-value=0.01).

Conclusions.

AChE and antioxidant levels are modified in dogs with mammary cancer. These variables are involved in various physiological functions, and thus, they might be related to disease pathogenesis.

Palavras-chave : Cancer; cholinergic system; FRAP; immunohistochemistry (Source: CAB).

        · resumo em Espanhol     · texto em Inglês     · Inglês ( pdf )