Abstract

ROSERO, Doris H; SALAZAR, Liliana  and  TOVAR, Maria Ana. Skeletal muscle and reperfusion injury: ultra structure, disease and regeneration: systematic review. Revista médica Risaralda [online]. 2015, vol.21, n.2, pp.58-68. ISSN 0122-0667.

Introduction: The tissue function is based on the cell association and communication through junctions or the extracellular matrix, which comprises connective tissue. Ischemia injury leads to changes to which the cells respond and it depends on duration and intensity of stimulus injury. In short periods of prolonged ischemia and reperfusion, skeletal striated muscle tissue shows changes in the predominance of muscle fiber types and components of the extracellular matrix intramuscular. Objective: To determine the changes which occur in skeletal muscle during prolonged reperfusion in both muscle fibers in its extracellular matrix. Methods: A systematic review was performed by searching for articles in English and Spanish published in journals indexed in databases Ovid Medline, PubMed, Science Direct and Wiley. MeSH descriptors used were skeletal muscle, ischemia, reperfusion, fast twitch fiber type, slow twitch fiber type, sarcomere and myoblast. The terms tissue and histology were coupled. Results: 81 relevant publications were selected and supplemented with images of skeletal muscles from samples processed at the Laboratory of Histology of the Universidad del Valle, Colombia. Conclusion: The recovery of muscle during ischemia followed by reperfusion, tends toward the normal histological and functional pattern. In some cases it is a slow process and even after several months has not been completed. Likewise, they may persist mild or moderate alterations in muscle contraction, given the changes that occur in the intramuscular extracellular matrix.

Keywords : skeletal muscle; ischemia; reperfusion; angiogenesis; myoblasts.

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