Abstract

OSPINA-RAMIREZ, Juan José et al. Risk Factors associated with congenital malformations: in a center of high complexity in a coffee region area in Colombia. Revista médica Risaralda [online]. 2018, vol.24, n.1, pp.14-22. ISSN 0122-0667.

Objective: to determine the association between sociodemographic factors, exposure to teratogens and maternal disease, with the presence of congenital malformations in a third-level center in the central western region of Colombia during the year 2013. Methods: An analytical case-control study was conducted And controls. We analyzed maternal and newborn variables, which were presented as frequencies and proportions and were evaluated using Chi2 (x2) and Fisher’s exact tests. To determine the association between each variable we calculated the Odds Ratio (OR) crude, and Odds Ratio (ORa) adjusted for the variables that presented a statistically significant difference, after this it was found by test of likelihood ratio that no differences were found Important between the complete and the reduced model, showing values of a more parsimonious model, with a goodness-of-fit test Hosmer-Lemeshow 0.19. Results: sociodemographic variables age and maternal occupation were found to be a risk for developing congenital malformations OR= 7.7 (2.4-24.5) and OR=2.01 (1.13-3.69), respectively. In the obstetric history, greater risk was found to have greater weight gain than the ideal with OR = 3.0a (1.3-6.7) and a weight gain lower than the ideal OR = 2.3a (1.1-4.9) and as protective factors being Child of the same father and conceive easy OR = 0.37C (0.2-0.8) P = 0.007 and OR = 0.20a (0.1-0.7), Conclusion: Age over 35 years, work outside and A weight gain greater than ideal, or weight gain less than ideal, are major risk factors for congenital malformations found in this study, easy conception is found as a protective factor for congenital malformations.

Keywords : genetics; Risk factor; Epidemiology; Surveillance.

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