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Revista Médica de Risaralda
Print version ISSN 0122-0667
Abstract
SOTO-ALFARO, Tania V; MUNOZ-MEDINA, Carlos E; RODRIGUEZ G, Jonathan J and PARRILLA-ALVAREZ, Pedro E. Clinical and histopathological effects of acute and subagude of the poison of Tityus breweri in hamsters myocardia. Revista médica Risaralda [online]. 2019, vol.25, n.2, pp.65-72. ISSN 0122-0667.
Scorpions of the genus Tityus present the largest distribution of the world, of greater clinical, epidemiological and more dangerous importance of the American continent. The toxins from its venom produce severe disturbance of the excitation and conduction processes of the nerve impulse. From the histopathological point of view structural changes have been observed in different tissues of mice, with the venom of several species of Venezuelan Tityus.
Objective:
To describe the acute and subacute clinical and histopathological effects of scorpion venom (Buthidae: T. breweri) on the hamster myocardium.
Method:
Experimental, exploratory, descriptive, analytical and correlational study. Hersters of both sexes of the genus Cricetus were obtained and venom of 26 T. breweri scorpions were obtained, 6 random hamsters were chosen, injecting intravenously (VIP) venom of Tityus breweri, 3 sacrificed at 30 minutes and the other 3 a The 60 minutes, 3 injected with distilled water constituted the control group.
Results:
Most of the exposed animals presented cholinergic and adrenergic type manifestations. The acute histopathological alterations observed were interfascicular edema and vascular congestion, perivascular lymphohistiocytic infiltrate. At the end of 12, 24, 48 and 72 hours of exposure of the venom, no histopathological changes were evidenced, which suggests that the repair processes of the damaged tissues were activated.
Conclusion:
T. breweri venom caused acute and subacute histological alterations in myocardial tissue in hamsters with no evidence of alteration in the control group.
Keywords : Tityus; scorpion; adrenergic agents.
