Abstract

GIL, Sandra J.; RAMIREZ, Camilo L.  and  GALINDO, Vladimir. Comparison of the Degree of Sedation, Anaesthetic Depth and Collateral Effects of Five Anaesthetic Protocols in Healthy Dogs. Rev. Med. Vet. [online]. 2011, n.21, pp.25-39. ISSN 0122-9354.

The purpose of this study was to compare the degree of sedation, anesthetic depth and collateral effects of five anesthetic protocols routinely used in healthy canine patients at the National University of Colombia. Fifteen adult (1-5 years old), mixed-breed dogs (5 males, 10 females), weighting 15-20 kg, were anaesthetized using the following protocols: 1. Atropine + Xylazine followed by Thiopental; 2. Atropine + Xylazine followed by Ketamine + Diazepam; 3. Acepromazine, followed by Atropine + Hydromorphone and then Thiopental; 4. Atropine + Hydromorphone followed by Diazepam and then Thiopental and; 5. Atropine + Hydromorphone followed by Diazepam and then Propofol. The animals were healthy and each one was anaesthetized with the five anesthetic protocols, with an interval of at least one week. No surgical procedures were performed. Significant differences were found in the degree of sedation between protocols, specifically regarding the need for restriction (p=0.0043), anesthetic depth (p=0.0183) and analgesia at 0 and 5 minutes post induction (p=0.0045 and 0.0233, respectively). As far as collateral effects are concerned, there were significant differences in parameters such as temperature loss (p=0.0137) and partial oxygen saturation (p=0.0001). There were no significant differences between protocols regarding important parameters, such as the frequency of arrhythmias (p=0.7404), but they were more severe when using protocol 1. The longest anesthetic times were observed during protocol 3. It is concluded that protocol 5 is superior to the others, since it provided an adequate anesthetic depth, with less severe collateral effects.

Keywords : sedation; anesthesia; collateral effects; protocols.

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