Abstract

INFANTE-LOPEZ, Dilany Vanessa; CESPEDES-GALVIS, Mileidy Fernanda  and  WILCHES-FLOREZ, Ángela María. CRISPR-CAS9: THE BIOETHICAL DEBATE BEYOND THE GERMLINE. pers.bioét. [online]. 2021, vol.25, n.2, e2529.  Epub May 19, 2022. ISSN 0123-3122.  https://doi.org/10.5294/pebi.2021.25.2.9.

The CRISPR-Cas9 system is a genetic editing technology that, in addition to expanding the possibilities for scientific research, promotes reflections associated with human dignity, biological control, therapy, and genetic improvement. Bioethical discussions on the challenges and repercussions of the CRISPR-Cas9 system are reviewed. As a result, bioethical questions tend to problematize the application to non-human organisms, primary research, and the human somatic and germline. In brief, it is necessary to increase the levels of safety and effectiveness so that the benefits outweigh the risks, while reducing bioethical concerns and increasing the credibility of the technique.

Keywords : Bioethical issues; clustered regularly interspaced short palindromic repeats; effectiveness; gene editing; risks and fringe benefits; Risk Assessment; safety.

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