Resumo

PEREZ MANCILLA, Ximena  e  MONTOYA CASTANO, Dolly. Endospore formation in Clostridium and its interaction with solventogenesis. Rev. colomb. biotecnol [online]. 2013, vol.15, n.1, pp.180-188. ISSN 0123-3475.

Solventogenesis and sporulation are mechanisms used by Clostridium cells to resist hostile environments. Sporulation has been studied using as a model what happens with Bacillus, but marked differences were recognized, particularly in the events that led the phosphorylation of the master controller Spo0A. Currently, a theory that claims that three orphan histidine kinases, different from Spo0B (histidin kinase) and spo0F (phosphotransferase) proteins in Bacillus, phosphorilate directly Spo0A in Clostridium activating transcription of different sigma factors which are similar in the two bacterial genera, has been supported. Spo0A protein, which belongs to the family of response regulators, behaves as an entity that has global regulatory interference on the processes of spore formation and solvents, modulating genes necessary to produce acetone and butanol. The understanding of this process has led researchers to employ different molecular techniques that increase the production of solvents, and remove the property of the cells to produce endospores. Reason why, this paper presents an updated summary of these two gene expression networks, connected by the master regulator spo0A.

Palavras-chave : sporulation; solventogenesis; phosphorylation; Clostridium; Spo0A.

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