Resumen

MARTINEZ SANCHEZ, Heimy Franceline et al. Healing effect of a chitosan-based gel obtained from the exoskeleton of white shrimp Litopenaeus vannamei and its evaluation in vivo. Rev. colomb. biotecnol [online]. 2014, vol.16, n.1, pp.45-50. ISSN 0123-3475.  https://doi.org/10.15446/rev.colomb.biote.v16n1.37989.

Skin problems in Mexico have steadily increased (62 %) by burns, wounds and diabetes mainly. To solve this problem, chitosan can be implemented; this polysaccharide has an antimicrobial and immunology activity against bacteria and fungi, accelerating healing. Therefore, synergistic effect of chitosan gel on the rate of healing, obtained from the exoskeleton of shrimp, that was evaluated. This was tested by applying it 1 cm² of inflicted wounds of 48 albino mice, of 45 days old and between 23 to 26 g of weight, during 14 days, and grouped into four treatments: 1) 0.15 % chitosan 2) 0.30 % chitosan, 3) commercial product 2 % Ketanserin and 4) A batch of untreated controls. The time required for healing without treatment was 14 days and with the utilization of 0.30 % chitosan gel was achieved in 7 days (P> 0.05) with the healing effect 58 % for the chitosan 0.15 and 64 % for chitosan 0.30.

Palabras clave : skin; wounds; gel; chitosan; healing.

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