SciELO - Scientific Electronic Library Online

 
vol.16 número1Consorcio microbiano nativo con actividad catalítica para remoción de índigo y surfactantes en agua residual industrial textil a través de una matriz de inmovilizaciónEl dicloruro de mercurio como desinfectante en la micropropagación del comino (Aniba perutilis Hemsley) índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

Links relacionados

  • En proceso de indezaciónCitado por Google
  • No hay articulos similaresSimilares en SciELO
  • En proceso de indezaciónSimilares en Google

Compartir


Revista Colombiana de Biotecnología

versión impresa ISSN 0123-3475

Resumen

ARIZA MARQUEZ, Yeimy Viviana; BELTRAN LOPEZ, Ángela Patricia; BRICENO BALCAZAR, Ignacio  y  ANCIZAR ARISTIZABAL, Fabio. Biological role and applications of miRNAs in breast cancer. Rev. colomb. biotecnol [online]. 2014, vol.16, n.1, pp.188-202. ISSN 0123-3475.  https://doi.org/10.15446/rev.colomb.biote.v16n1.44287.

MiRNAs are small RNAs that are involved in various processes of gene regulation by RNAi and play a key role in various biological, such as cell proliferation, differentiation and apoptosis processes. Consequently, the altered expression of miRNAs contribute to human disease, including cancer. In this review, we will focus on the recent findings of miRNAs that affect the development of cancer, particularly breast cancer, simultaneously evaluate their regulatory mechanisms , their classification , their use as markers of tumor invasion, drug susceptibility and further explore the utility of miRNAs in the diagnosis, monitoring and individualize treatment. Finally found that miRNAs represent a great alternative for understanding the molecular basis of implicit tumor processes in breast cancer and once all targets are known, it will be possible to elucidate at least in part this complex and multigenic process, aided by tools such as generation of databases, to report the differential expression of miRNAs, elements that allow us to preventive medicine and improve the quality of life of patients and their families.

Palabras clave : breast cancer; miRNAs; anti-oncomir; Oncomir; post-transcriptional regulation; RNAm.

        · resumen en Español     · texto en Español     · Español ( pdf )