Resumo

CELIS BUSTOS, Yamile Adriana; RUBIO, Vivian Vanesa  e  CAMACHO NAVARRO, María Marcela. Evolutionary origin of antibiotic resistance, a historical perspective. Rev. colomb. biotecnol [online]. 2017, vol.19, n.2, pp.105-117. ISSN 0123-3475.  https://doi.org/10.15446/rev.colomb.biote.v19n2.69501.

Antimicrobial resistance is a natural aspect of bacterial evolution that can result from mutations or acquisition of foreign genes. Various views on the origin of this resistance explain the ability of these organisms to acquire new features. Lamarck and Darwin’s theories of evolution have led to experiments designed to explore the origin of bacterial variation and the emergence of new features. These experiments show that antimicrobial resistance is related to mutations in chromosomal genes and/or transfer of extrachromosomal genetic elements that can be expressed based on the antibiotic pressure exerted. The main experiments and findings that seek to explain the phenomenon of antibiotic resistance are reviewed here in.

Palavras-chave : antibiotic resistance; evolution; adaptation; mutation; horizontal gene transfer.

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