Abstract

VELASQUEZ C., Luisa-Fernanda; ROJAS T., Dan'ithza S.  and  CERON S., Jairo A.. Proteins of Bacillus thuringiensis with cytotoxic activity: Parasporins. Rev. colomb. biotecnol [online]. 2018, vol.20, n.2, pp.89-100. ISSN 0123-3475.  https://doi.org/10.15446/rev.colomb.biote.v20n2.73668.

Cry toxins from Bacillus thuringiensis (Bt) have been recognized for their biocontrol action against insect pests. Recently it has been described some strains of Bt produce proteins without insecticidal activity, but when cancer cell lines of different types are exposed to these proteins they have demonstrated cytotoxic activity. These proteins have been called parasporins (PS) and are a potential alternative for the treatment of cancer because they have high cytotoxicity in different cancer cell lines, and null or low toxic activity in normal cells.

Keywords : Cancer; cellular line; receptor; toxin Cry.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )