Abstract

MURILLO USUGA, Carlos Augusto  and  ESCOBAR SIERRA, Diana Marcela. Biofunctionalization of silk fibroin-based surfaces for potential use in cardiovascular applications. Rev. colomb. biotecnol [online]. 2023, vol.25, n.2, pp.6-15.  Epub Jan 31, 2024. ISSN 0123-3475.  https://doi.org/10.15446/rev.colomb.biote.v25n2.103560.

In the present work, fibroin, and polyvinyl alcohol (PVA) - based films were biofunctionalized using two different techniques, the first by carbodiimide coupling and second by exploiting electrostatic interactions, seeking to achieve antithrombogenic behavior on the surface of the manufactured films for their potential use as biomaterials for the manufacture of cardiovascular implants. The biofunctionalized samples were submitted to the blood clotting test to verify the success of said biofunctionalization. The results showed that the samples biofunctionalized by carbodiimide coupling, in addition to presenting a higher antithrombogenic activity than those biofunctionalized by taking advantage of electrostatic interactions, presented contact angles values closer to those of the materials for the manufacture of cardiovascular implants, and that also, the biofunctionalization does not significantly affect the mechanical and surface properties of the fabricated films

Keywords : Biofunctionalization; antithrombogenic activity; surface; fibroin.

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