Abstract

TRIBINO E., Gabriel. DEVELOPMENT OF A PHARMACOVIGILANCE PILOT PROGRAM IN THE SAN JUAN DE DIOS HOSPITAL OF ZIPAQUIRA. rev.udcaactual.divulg.cient. [online]. 2008, vol.11, n.2, pp.51-60. ISSN 0123-4226.

Pharmacovigilance hospital programs play a key role in the consolidation of a national program and the continuous improvement of health care. The goal of this study was to develop a pharmacovigilance pilot program in a level two hospital and identify the salient clinical features of the adverse reactions detected. The program was presented before the hospital's Epidemiologic Surveillance Committee and the professionals of the wards included (internal medicine, surgery, obstetrics and gynecology and emergency). Information was collected by spontaneous reporting by the medical staff and intensive follow-up, carried out by the researcher during a six month period (march-september 2006). A format based on the INVIMA reporting sheet was used. Reports presented periodically to the committee were produced. Sixty adverse drug reactions were detected, of which 48 occurred in hospitalized patients (incidence 19X1000); eight led to hospitalization and four were detected in the emergency ward. Adverse reactions affecting gastrointestinal system were the most frequent ones reported in hospitalized patients (27%). Hypoglycemia was the adverse reaction that more often led to hospitalization (62.5%). 82% of the adverse reactions were reported by the author and 18% by the medical staff. Some of the clinical features of the adverse reactions detected are similar to those found in studies performed at level three hospitals. The rate of spontaneous notification was low. The features of the program match those of a second level hospital and allow its continuity.

Keywords : Pharmacoepidemiology; adverse effects; epidemiologic surveillance; pilot projects; hospitals, public.

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