Resumo

CRUZ A., Jorge; PEREZ Z., Juan; URREA Q., Martha  e  MESA E., Henry. EFFECT OF SILDENAFIL CITRATE IN CHRONIC LIVER DISEASE PROGRESSION IN A MURINE EXPERIMENTAL MODEL. rev.udcaactual.divulg.cient. [online]. 2013, vol.16, n.1, pp.53-60. ISSN 0123-4226.

Medical treatment of cirrhosis is palliative, being the hepatic transplant the only long-term cure but although not an accessible alternative. No effective therapeutic regimen that could prevent the progression of cirrhosis has been established. The effect of the sildenafil citrate (SC) was evaluated in Wistar rats with hepatic damage induced with carbon tetrachloride (CCL4). The project had the support of the ethic committee of the University of Caldas to experiment with animals.The animals were distributed in seven treatments. Normal control (No medicine); control CCL4; CS 10mg/kg; SC 25mg/kg; SC 50mg/kg; CCL4 + SC 10mg/kg; CCL4 + SC 25mg/kg; CCL4 + SC 50mg/kg. The CCL4 was given twice a week through subcutaneous route, meanwhile the SC was administered within the peritoneum (IP) route three times a week. Samples for the plasmatic measurement were taken of the aspartato aminotransferase (AST), as well as the histopathology tests every two weeks. The analysis of the results was done through an analysis of unifactorial variance. The level of statistical significance was taken as P<0.05. It was found that treatments of CCL4 + SC showed important increases of the enzyme AST, being the dose 10mg/kg the one with a statistically significant increase (P<0.05). Significant differences were not observed in the histopathology evaluation of the variables of cellular infiltration, vacuolization and fibrosis when comparing the treatments CCL4 + SC with its respective control group. The treatment with SC did not affect the progression of the hepatic fibrogenesis and noticeably increased the levels of AST, suggesting a possible toxic effect.

Palavras-chave : CCL4; hepatic fibrogénesis; histopatology; AST.

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