Abstract

RUIZ-BAQUERO, Jhon; CAMACHO-ROMERO, Oscar; BOLIVAR-GONZALEZ, Samir  and  CASTRO-ZAFRA, Álvaro. In vitro anticoagulant activity of the ethanolic extract of the leaves of two species of the family Euphorbiaceae. rev.udcaactual.divulg.cient. [online]. 2021, vol.24, n.2, e1681.  Epub Dec 06, 2021. ISSN 0123-4226.  https://doi.org/10.31910/rudca.v24.n2.2021.1681.

Cardiovascular diseases (CVD) are a group of disorders of the heart and blood vessels, which correspond to the principal causes of death in the world. In the search for alternatives to this problem, medicinal plants of the Euphorbiaceae family have been investigated for therapeutic purposes to prevent, attenuate or cure the effects generated for these illnesses. The objective of this work was to know the phytochemical profile and evaluate the anticoagulant activity in vitro of the ethanolic extracts of the leaves of Croton malambo and Acalypha hispida on human plasma. For this, extract of their leaves was obtained, and phytochemical screening was performed, as well as the evaluation of the Activated Partial Thromboplastin Time (aPTT) and the Prothrombin Time (TP). The phytochemical profile confirmed the presence of alkaloids, tannins, flavonoids, leucoanthocyanidins, phenols, sesquiterpene lactones, cardiotonic glycosides, and terpenes. In the anticoagulant activity, the inhibition of coagulation in the intrinsic pathway was evidenced, obtaining significant results for aPTT, unlike the TP test where the results obtained were like the control. This research demonstrates the effectiveness of the plant with anticoagulant action since they significantly induce a longer prolongation of the clotting time, both species showed higher activity at 200 mg/mL.

Keywords : Acalypha hispida; Croton malambo; Medicinal plants; Activated Partial Thromboplastin Time; Prothrombin Time.

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