Resumen

RIVAS, Giovanna; OLIVELLA, Fabio; CARRENO, José  y  RODRIGUEZ, Viviana. Patients with locally advanced rectal cancer on neoadjuvant treatment with chemo-radiotherapy in the Instituto Nacional de Cancerología during 2010. rev.colomb.cancerol. [online]. 2013, vol.17, n.1, pp.18-24. ISSN 0123-9015.

Objectives: To describe the sociodemographic and clinical characteristics of a group of patients with locally advanced rectal cancer treated with neoadjuvant chemo-radiotherapy, and to make a situational diagnosis of the management. Methods: A case series study was conducted using the clinical information of 41 patients treated in the Instituto Nacional de Cancerología during the year 2010. Results: The mean age of the patients studied was 61 years, and 60% were male. The Karnofsky functional state was equal or greater than 70%. The neoadjuvant scheme most used was 5-fluorouracil and leucovorin in boluses, concomitant with radiotherapy. Of the 41 patients, 30 completed the treatment with good tolerance; 21 required surgery, with preservation of the sphincter in 10 of them; 18 achieved a pathological response; 14, partial and 4, complete. Conclusion: The patients with locally advanced rectal cancer who received neoadjuvant treatment with chemo-radiotherapy in the Instituto Nacional de Cancerología during the year 2010 were, mainly males with a good functional state. The principal chemotherapy scheme employed was 5-fluorouracil and leucovorin in boluses, due to which resectability of the tumour, preservation of the sphincter, and a pathological response in approximately half of the patients, was achieved.

Palabras clave : Rectal neoplasms; Drug Therapy; Radiotherapy; Combined Modality Therapy; Fluorouracil.

        · resumen en Español     · texto en Español     · Español ( pdf )