Resumo

RODRIGUEZ, Josefa A; MARTINEZ, Lina M; CRUZ, Nataly  e  COMBITA, Alba L. Gene therapy for cancer treatment. rev.colomb.cancerol. [online]. 2014, vol.18, n.1, pp.27-40. ISSN 0123-9015.

Cancer is a complicated disease of unknown etiology. Genetic and epigenetic factors are associated with an increased risk for developing this disease. Despite the progress in the traditional cancer therapies, the prognosis of patients has not improved significantly. Studies on the molecular pathogenesis of cancer have demonstrated the existence of molecular targets with therapeutic potential. Furthermore, knowledge of the viral genome function and replication, as well as of the mechanisms of tumor cell infection, have made it possible to develop an ideal tool for gene therapy against cancer and thus, enable the transfer of knowledge from basic to clinical research for the benefit of patients. This article reviews different methodologies developed to design a cancer gene therapy and its clinical application for treating cancer, addressed from various biological contexts.

Palavras-chave : Mutation compensation; Molecular chemotherapy; Antiangiogenic gene therapy; Viral oncolysis; Genetic immunopotentiation.

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