Abstract

ARANGO, Natalia; BONILLA, Carlos  and  SANCHEZ, Ricardo. Management of osteosarcoma with Rizzoli therapy in routine services in a developing country. rev.colomb.cancerol. [online]. 2014, vol.18, n.2, pp.69-77. ISSN 0123-9015.  https://doi.org/10.1016/j.rccan.2014.05.001.

Objective: To describe the clinical and epidemiological characteristics of patients with osteosarcoma high grade limb osteosarcoma treated between 2007 and 2010 using Rizzoli 2 or Rizzoli 4 protocols in the National Cancer Institute, Colombia. Materials and methods: An analysis was made of the medical histories of patients with limb osteosarcoma who had received treatment with the Rizzoli 2 or Rizzoli 4 protocol. Descriptive statistics were used and survival and recurrence rates were estimated. Results: A total of 18 patients were found that had received treatment using the Rizzoli protocol. The mean age was 25 years (SD=10.2) and the most frequent anatomical location was in the femur. Surgery was performed on 15 of the 18 patients who received pre-operative chemotherapy, with limb salvage being achieved in 9 (60%) of them, and the remainder required amputation. A good pathological response was observed in the 15 patients who received surgery (tumor viability ≤ 10%) in 5 (33.33%). In the follow up at 2 years, 57% of the patients were still alive. The most frequent non-hematological adverse event was a grade 3 increase in transaminases. The most frequent hematology event was grade 2 leukopenia and grade 3 neutropenia of the 18 patients, 7 of them dropped out of the treatment (2 during neoadjuvant and 5 during adjuvant). Conclusions: The use of the Rizzoli 2 and 4 protocols in this population gave lower response, limb salvage, and overall survival rates than those reported in other publications.

Keywords : Osteosarcoma; Chemotherapy; Amputation; Limb salvage.

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