Abstract

PARRA-MEDINA, Rafael; OLAYA, Natalia; VILLAMIZAR-RIVERA, Nicolás  and  MORALES, Samuel D.. Indolent CD8-positive t-cell lymphoid proliferation: on purpose three cases of facial commitment. rev.colomb.cancerol. [online]. 2017, vol.21, n.1, pp.38-43. ISSN 0123-9015.  https://doi.org/10.1016/j.rccan.2016.04.004.

Primary cutaneous indolent CD8-positive lymphoid proliferation is a recent variant of cutaneous T lymphoma that is characterized by nodule, papule or plaque erythematous with slow growth that can affect the facial or extrafacial region. In the histopathology study it is characterized by an infiltration of monomorphic T lymphocytes throughout the dermis with presence of Grenz zone and absence of epidermotropism. The infiltrate is characteristically CD 8+ and CD3+ TIA-1+ CD4-, CD56- CD30, PD-1, Granzyme B- and negative EBER. Ki-67 Proliferación linfoide indolente cutánea CD8 positiva a propósito de tres casos proliferation index is less than 10% and clonal T-cell receptor gene rearrangements. Clinical follow-up is favorable and has not been observed systemic involvement. We present three cases with facial involvement (two cases in ear and one case with nasal commitment) with typical clinical presentation, histopathological findings (curiously a case with clear cell change) and clonality studies.

Keywords : T-cell lymphoma; CD8+; Indolent proliferation; Rearrangements; TCR; Latin America.

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