Abstract

BAUTISTA-TOLOZA, Leonardo; MARTINEZ, Humberto  and  BONELL-PATINO, Orlando. Intraparenchymal haematoma of the central nervous system associated with Dasatinib in the treatment of chronic myeloid leukaemia in accelerated phase. Presentation of two cases and review of literature. rev.colomb.cancerol. [online]. 2018, vol.22, n.4, pp.151-156. ISSN 0123-9015.  https://doi.org/10.1016/j.rccan.2017.10.002.

Two clinical cases are presented on patients with chronic myeloid leukaemia in accelerated phase, who were admitted to hospital for initiation of targeted therapy with tyrosine kinase inhibitors (Dasatinib). Intraparenchymal bleeding in the central nervous system was subsequently observed. A review was also made on the available literature on bleeding-related adverse events associated with Dasatinib and the possible determining factors of this outcome.

Keywords : Chronic myeloid leukaemia; Dasatinib; Intracerebral haemorrhage; Adverse effect.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )