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Revista Colombiana de Cancerología

Print version ISSN 0123-9015

Abstract

FIERRO-MAYA, Luis Felipe; MEJIA-VIDAL, Liliana; QUINTERO-CADAVID, Camilo Andrés  and  TAPIERO-GARCIA, Mireya. Malignant hypercalcaemia in patients with neuroendocrine tumours. Report of 2 cases of parathyroid hormone-related peptide-secreting pancreatic tumours. rev.colomb.cancerol. [online]. 2018, vol.22, n.4, pp.162-168. ISSN 0123-9015.  http://dx.doi.org/10.1016/j.rccan.2017.10.003.

Parathyroid hormone-related peptide-mediated hypercalcaemia (PTH-rp) is rare in patients with neuroendocrine tumours. The clinical cases are thus presented on two patients with pancreatic neuroendocrine tumours with liver metastases, but without bone involvement and with hypercalcaemia associated with elevated PTH-rp and with PTH suppressed. In both cases, it was possible to temporarily bring the calcium levels back to normal with the use of somatostatin analogues, but during the course of the disease, the addition of bisphosphonates was required in one of them.

With the discussion of these cases and the review of the literature and similar published cases, it is hoped to contribute to provide better knowledge of this disease.

Keywords : Hypercalcaemia; Parathyroid Hormone Related Protein; Pancreatic Neoplasia.

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