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Infectio

Print version ISSN 0123-9392

Abstract

LIZARAZO, JAIRO et al. Opportunistic infections of the Central Nervous System (CNS) occurring in HIV infected patients from Erasmo Meoz Hospital in Cúcuta, Colombia. Infect. [online]. 2006, vol.10, n.4, pp.226-231. ISSN 0123-9392.

Objective. To describe the opportunistic infections of the central nervous system occurring in HIV infected patients diagnosed and treated in a third level hospital in northeast Colombia. Design. Descriptive, observational study based on the review of clinical records. Place. Erasmo Meoz University Hospital in Cúcuta, Colombia. Population. Patients living with HIV attended at the Hospital during the 1995-2005 period. Measurements. Frequency of the analyzed variables. Results. One hundred thirty one CNS infections were found. Most of the patients were males (72.5%), young adults (mean age: 33.8 years) from Norte de Santander (94.7%). The CNS infections diagnosed were Toxoplasma gondii encephalitis (56.5%), meningeal cryptococcosis (38.9%), meningeal tuberculosis (4.6%). Only 31.3% patients were receiving Highly Active Antiretroviral Therapy (HAART). CNS infection defined AIDS in 79.4% of the cases. 93.0% of the patients had <200 CD4+ cells/mm3; only 42% survived 6 months after the diagnosis of the opportunistic infection. In patients with cerebral toxoplasmosis survival was 50% whereas in patients with meningeal cryptococcosis it was 37%. Conclusion. Central nervous system infections are very common in our HIV infected population and they have a great impact on patient’s survival.

Keywords : toxoplasmosis; cryptococcosis; meningeal tuberculosis; acquired immune deficiency syndrome.

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