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Infectio

Print version ISSN 0123-9392

Abstract

PATINO, Juan Camilo; VELILLA, Paula Andrea  and  RUGELES, María Teresa. Factors influencing the course of type one human immunodeficiency virus infection in individuals classified as long term non-progressors. Infect. [online]. 2009, vol.13, n.2, pp.111-121. ISSN 0123-9392.

The natural history of type one human immunodeficiency virus infection (HIV-1) is a variable process that has allowed identifying different patterns of progression. Among them, there is a group of individuals known as long-term non-progressors (LTNP). LTNP are characterized for being asymptomatic for long periods of time, showing no evidence of immune deterioration and having low or undetectable viral loads in absence of antiretroviral treatment. Different immunologic, genetic and viral factors have been associated with the pattern of progression. Immunological factors include both, innate and adaptive mechanisms; genetic factors are related with genes of the chemokines family as well as genes of the major histocompatibility complex. On the other hand, viral factors are related to the genetic variability and replication ability of the virus. The disease pattern that is established depends on the interrelations of all these factors, which finally account for the type of anti- HIV-1 immune response developed and the infectious capacity of the virus.

Keywords : HIV-1; long-term non-progressors; natural resistance.

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