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Print version ISSN 0123-9392


DIAZ, Juan Carlos  and  FERNANDEZ, Liliana. Trimethoprim induced hyperkalemia in a patient with primary adrenal insufficiency. Infect. [online]. 2010, vol.14, n.3, pp.223-226. ISSN 0123-9392.

Hyperkalemia induced by trimethoprim therapy is a frequent, yet less thought-off complication associated with its use. Initially described in 1983, it has been reported in several different patient populations; nonetheless, some groups of patients have a higher risk of presenting it, amongst them patients with adrenal insufficiency. We describe a patient with primary adrenal insufficiency who developed hyperkalemia and hyponatremia after trimethoprimsulfamethoxazole therapy. Generally, drug suspension is all that is required to return potassium to normal levels; in our patient, a temporary increase in the steroid dose was also used, achieving an excellent clinical response.

Keywords : trimethoprim sulfametoxazol; hyperkalemia; hyponatremia; adverse effects; adrenal insufficiency.

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