SciELO - Scientific Electronic Library Online

 
vol.15 issue1Bacteremia due to methicillin-resistant Staphylococcus aureus in intensive care unit: of prognostic studiesMultiple brain abscesses caused by Listeria monocytogenes in a patient infected with human immunodeficiency virus, the first case reported in Colombia author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google

Share


Infectio

Print version ISSN 0123-9392

Abstract

VELANDIA, Myriam L  and  CASTELLANOS, Jaime E. Dengue virus: structure and viral cycle. Infect. [online]. 2011, vol.15, n.1, pp.33-43. ISSN 0123-9392.

Dengue virus (DENV) is responsible for the clinical entity known as dengue that is a great concern for economy and public health of tropical countries. This flavivirus is a single strand RNA virus that after their translation and replication in host cells produces three structural and seven non-structural proteins with specific function in replication or cell binding process that we will describe here. Intracellular viral cycle has begun to be described and this knowledge will impact the rational design of new antiviral drugs. Patients suffering dengue can have an undifferentiated fever or in the severe cases, show an aberrant immunological activation process that lead to soluble inflammatory mediators secretion, affecting tissue function, mainly endothelium. This organ dysfunction is associated with plasma leakage and coagulatory imbalance. Despite it has been recently described some host factors associated with severity of infection, it remains unknown some aspects of viral biology or the role of DENV proteins in disease pathogenesis. This article pretends to make an updated revision about DENV structure, cell viral cycle and introduce some concepts about dengue immunopathogenesis.

Keywords : Dengue Virus; structure, assembly; immunopathogenesis.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License