Abstract

JIMENEZ, Adriana  and  FAJARDO, Claudia. Activity of Doripenem compared to Meropenem against Pseudomonas aeruginosa isolates at Tertiary Care Teaching Hospital in Bogotá (Colombia). Infect. [online]. 2012, vol.16, n.4, pp.199-203. ISSN 0123-9392.

objective: The aim of this study was to evaluate the in vitro activity of doripenem compared to meropemen against local isolates of Pseudomonas aeruginosa (P. aeruginosa) . Materials and methods: At the San José Hospital in Bogotá-Colombia, a 300-bed teaching hospital, 83 nonduplicate isolates of P. aeruginosa were collected between 2009 and 2011.Meropenem and Doripenem Minimum Inhibitory Concentration (MIC) were determined by the E test method. The 2012 Clinical and Laboratory Standards Institute breakpoints for carbapenems were applied. Results: The global susceptibility of P. aeruginosa isolates to meropemen was 69% and to doripenem was 75%, being the CIM 50 and 90 (ug/mL) of 0.75 and 28.8 for meropenem and of 0.64 and 15.2 for doripenem. Conclusions: The MIC of doripenem was lower than the corresponding MIC of meropenem. It is required to carry out local studies of this type in order to make adjustments to the institutional antibiotics protocol.

Keywords : Doripenem; Resistance; Pseudomonas aeruginosa.

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