SciELO - Scientific Electronic Library Online

 
vol.17 número1Colombian Consensus on Nosocomial Pneumonia 2013Diagnosis of Chagas disease in Pregnant Women and Newborns in Moniquirá and Mira-Florez, Boyacá, Colombia índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Journal

Artigo

Indicadores

Links relacionados

  • Em processo de indexaçãoCitado por Google
  • Não possue artigos similaresSimilares em SciELO
  • Em processo de indexaçãoSimilares em Google

Compartilhar


Infectio

versão impressa ISSN 0123-9392

Resumo

GALINDO-ORREGO, Pablo; MUESES-MARIN, Héctor F; GALINDO-QUINTERO, Jaime  e  MARTINEZ-CAJAS, Jorge L. Transmitted HIV Resistance in ART-Naïve Patients in Cali, Colombia, 2010 . Infect. [online]. 2013, vol.17, n.1, pp.19-27. ISSN 0123-9392.

Introduction: In Colombia, little has been published on HIV-transmitted drug resistance, and genotype resistance testing (GART) is not recommended for antiretroviral therapy (ART)-Naïve patients, according to Colombian HIV guidelines. We conducted a study to determine the frequency of HIV-transmitted drug resistance from a sample of ART-Naïve patients attending an HIV clinic in Cali, Colombia. Methodology: A cross-sectional study was carried out on 152 eligible adult patients with confirmed HIV infection who were ART-Naïve, had HIV GART results, and who agreed to participate. The recruitment period was from 2008 to 2010. Resistance mutations included in the analysis are those defined by the WHO- 2009 and IAS-USA, 2010. Additional data was collected, including socio-demographic characteristics and HIV-related conditions. Results: The mean age was 32 ±10.2 years; 76% were men. Frequency of transmitted drug resistance was 6.6%, but some level of resistance was found in up to 11.8% of total cases (if IAS-USA 2010 mutations were also included). The most common mutations were K103N/S (2%), F77L (2%) and M46L (2%). NNRTI mutations were found in 5.3%, NRTI mutations in 3.9% and PI mutations in 2% of the sequences. The only factor associated with primary resistance was the duration of HIV infection.

Palavras-chave : HIV; Resistance; Mutation; Genotyping; Colombia.

        · resumo em Espanhol     · texto em Espanhol     · Espanhol ( pdf )