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Infectio

Print version ISSN 0123-9392

Abstract

SARMIENTO, Ladys et al. Hepatic glucogen in cases with severe dengue: histopathological changes. Infect. [online]. 2013, vol.17, n.4, pp.172-176. ISSN 0123-9392.

Background: Dengue virus affects various organs, but the liver is the main target of damage and where the most severe damage can occur. There are few studies on the histological changes in the liver during dengue infection. Aims: To analyze the histopathological post-mortem alterations in livers from patients with Methods: We revised serial liver sections, which were stained and tested for glycogen, from 20 patients with severe dengue. Results: We found loss of cytoplasmic glycogen in all cases analyzed and the presence of intranuclear glycogen in two of them. Conclusions: This is the first report of the presence of intranuclear glycogen masses during severe dengue.

Keywords : Dengue; severe, dengue; Dengue hemorrhagic fever; Glycogen; Hepatocyte; Diastase.

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