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Infectio

Print version ISSN 0123-9392

Abstract

VELEZ L, Juan Diego  and  CARRILLO C, Diana Cristina. Cutaneous leishmaniasis and liposomal amphotericin B: Case report. Infect. [online]. 2013, vol.17, n.4, pp.201-204. ISSN 0123-9392.

Cutaneous leishmaniasis is a zoonosis caused by various species of Leishmania parasite. There are two types, known as New World and Old World leishmaniasis, which are caused by different species. The most common form of leishmaniasis in our area is mucocutaneous, which rarely has systemic involvement, even in HIV-positive patients. Glucantime is the first choice of therapy, or alternatively miltefosine, both of which have significant toxicity and can fail in a substantial number of cases. The alternative choice of treatment for these patients is amphotericin B, from which the liposomal form has less renal toxicity but a high cost and low availability. We report the case of a patient with chronic renal disease and cutaneous leishmaniasis, in whom Glucantime was contraindicated and therapeutic failure with miltefosine occurred. He was treated with liposomal amphotericin B in a single dose of 15mg/kg with adequate tolerance, no significant deterioration of renal function and resolution of skin lesions after 30 and 60 days of follow up.

Keywords : Leishmaniasis; Cutaneous [therapy]; Amphotericin B; Amphotericin B [pharmacokinetics]; Amphotericin B [adverse effects].

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