Abstract

CIFUENTES-CIFUENTES, Yolanda  and  GRANADILLO-VASQUEZ, Tania. Polymerase chain reaction in the diagnosis of congenital infection cytomegalovirus: A purpose of a case of aseptic meningitis . Infect. [online]. 2015, vol.19, n.4, pp.175-178. ISSN 0123-9392.  https://doi.org/10.1016/j.infect.2015.02.003.

We report a case of a newborn with persistent thrombocytopenia, hematuria, proteinuria, as well as increased proteins and leukocytes in cerebrospinal fluid, with a non-reactive VDRL. His mother had history of gestational syphilis. IgM levels against cytomegalovirus, rubella, toxoplasma, herpes i and ii were negative, which led to suspicion of congenital syphilis with central nervous system involvement. A polymerase chain reaction test for cytomegalovirus showed 181.171 copies/ml in serum. The newborn was treated with intravenous ganciclovir at 12 mg per kg body weight for 21 days and a 10% solution of human cytomegalovirus hyperimmune immunoglobulin, administered as follows: 4 ml per kg body weight on days 0, 4 and 8, followed by 2 ml per kg weight on days 12 and 16. The clinical outcome was satisfactory. This study highlights the usefulness of PCR for the diagnosis of congenital CMV infection.

Keywords : Cytomegalovirus infections; Thrombocytopenia; Aseptic meningitis.

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