Resumen

MONTUFAR ANDRADE, Franco E.  y  GRUPO DE INVESTIGACION GIERI et al. Coagulase-negative Staphylococcus bacteremia with Vancomycin minimum inhibitory concentrations ≥ 2 . Infect. [online]. 2016, vol.20, n.1, pp.3-8. ISSN 0123-9392.  https://doi.org/10.1016/j.infect.2015.05.001.

Introduction: Currently, coagulase-negative Staphylococcus (CNS) bacteremia is an infection that leads to significant morbidity and mortality given the type of patients affected and the recent changes in antimicrobial susceptibility. Objective: To describe the characteristics of patients with CNS blood isolates with vancomycin MIC ≥ 2. Methodology: Descriptive observational study on hospitalised patients ≥ 2 15 years of age. Results: Of 130 isolates, 38 (29,23%) contained vancomycin MIC ≥ 2. The median age was 54 years and the male:female ratio was 1.37:1. The most frequent species were S. epidermidis (71.1%), S. haemolyticus (13.2%) and S. hominis (7.9%). Some 44.7% of patients had a history of immunosuppression, including: neoplasms (28.9%), rheumatologic disease (5.2%) and HIV (2.6%). Some 81,5% had vascular access; 97.3% had previous hospitalisations and 60.5% had required intensive care. A total of 81.4% of the patients had prior exposure to antibiotics and the most commonly used were beta-lactams (78.9%) and vancomycin (50%). Infective endocarditis was documented in 2.6%. Of the CNS isolates with vancomycin MIC ≥ 2, 26.3% were sensitive to methicillin. The main treatments received were: daptomycin (31.5%), vancomycin (21%), linezolid (15.7%) and betalactams (10.5%). Combined therapy was performed in 10.5%. The overall mortality was 15.8% and attributable mortality was 33.3%. Conclusion: A significant proportion of isolates were hetero-resistant to vancomycin. The bacteremia was associated with vascular access, previous hospitalisations, intensive care treatments and prior antibiotic exposure. Immunosuppression is the most important comorbidity and mortality is significant.

Palabras clave : Coagulase negative Staphylococcus; Vancomycin; Minimum inhibitory concentration; Bacteremia.

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